Endoplasmic reticulum stress in elderly patients with COVID-19: potential of melatonin treatment

GT Yiang, CC Wu, CL Lu, WC Hu, YJ Tsai, YM Huang… - Viruses, 2023 - mdpi.com
Aging processes, including immunosenescence, inflammation, inflammasome formation,
genomic instability, telomeric attrition, and altered autophagy, are involved in viral infections …

ER stress and autophagy induced by SARS-CoV-2: The targets for melatonin treatment

JA Boga, A Coto-Montes - Melatonin Research, 2020 - melatonin-research.net
Abstract Coronavirus disease 19 (COVID-19) is a viral disease caused by the new
coronavirus SARS-CoV-2. Like other coronaviral infections, SARS-CoV-2 causes oxidative …

Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19

A Banerjee, SJ Czinn, RJ Reiter, TG Blanchard - Life sciences, 2020 - Elsevier
The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic
with an urgent need for understanding the mechanisms and identifying a treatment. Viral …

A review of the potential effects of melatonin in compromised mitochondrial redox activities in elderly patients with COVID-19

WL Su, CC Wu, SFV Wu, MC Lee, MT Liao… - Frontiers in …, 2022 - frontiersin.org
Melatonin, an endogenous indoleamine, is an antioxidant and anti-inflammatory molecule
widely distributed in the body. It efficiently regulates pro-inflammatory and anti-inflammatory …

Can melatonin reduce the severity of COVID-19 pandemic?

A Shneider, A Kudriavtsev… - International reviews of …, 2020 - Taylor & Francis
The current COVID-19 pandemic is one of the most devastating events in recent history. The
virus causes relatively minor damage to young, healthy populations, imposing life …

Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease

DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

DX Tan, R Hardeland - Melatonin Research, 2020 - melatonin-research.net
The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19,
and avian flu is often caused by the uncontrolled innate immune response and destructive …

COVID-19: Melatonin as a potential adjuvant treatment

R Zhang, X Wang, L Ni, X Di, B Ma, S Niu, C Liu… - Life sciences, 2020 - Elsevier
This article summarizes the likely benefits of melatonin in the attenuation of COVID-19
based on its putative pathogenesis. The recent outbreak of COVID-19 has become a …

Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19

MA El-Missiry, ZMA El-Missiry, AI Othman - European journal of …, 2020 - Elsevier
Coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a newly
discovered highly pathogenic virus that was declared pandemic in March 2020 by the World …

Possible application of melatonin in long COVID

DP Cardinali, GM Brown, SR Pandi-Perumal - Biomolecules, 2022 - mdpi.com
Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger
for months beyond the acute stage of SARS-CoV-2 infection,“long COVID”. Among the long …