Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …

Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

Gene expression is modulated by epigenetic factors that come in varying forms, such as
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …

Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …

Introduction DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …

DNA methylation is a vital component of the epigenetic machinery that orchestrates changes
in multiple genes and helps regulate gene expression in all known vertebrates. We …

Abstract The formation of 5-hydroxymethylcytosine (5hmC), a key intermediate of DNA
demethylation, is driven by the ten eleven translocation (TET) family of proteins that oxidize …

Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA
methylation has been suggested to be a central mechanism in development, some disease …