Abnormal homocysteine metabolism: an insight of Alzheimer's disease from DNA methylation

T Pi, B Liu, J Shi - Behavioural Neurology, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a chronic neurodegenerative disease in the central nervous
system that has complex pathogenesis in the elderly. The current review focuses on the …

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia

M Bednarska-Makaruk, A Graban… - Experimental …, 2016 - Elsevier
Epigenetics (particularly DNA methylation) together with environmental and genetic factors,
are key to understanding the pathogenesis of many diseases including dementia …

Alterations in global DNA methylation and hydroxymethylation are not detected in A lzheimer's disease

T Lashley, P Gami, N Valizadeh, A Li… - Neuropathology and …, 2015 - Wiley Online Library
Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …

The role for oxidative stress in aberrant DNA methylation in Alzheimer's disease

J L. Fleming, C J. Phiel… - Current Alzheimer …, 2012 - benthamdirect.com
Alzheimer's disease (AD) is a common, progressive neurodegenerative disorder without
highly effective therapies. The etiology of AD is heterogeneous with amyloid-beta plaques …

Epigenetics in Alzheimer's disease: a focus on DNA modifications

N Coppieters, M Dragunow - Current pharmaceutical design, 2011 - ingentaconnect.com
Epigenetic alterations have been associated with several human diseases including
Alzheimer's disease (AD). AD is a complex neurodegenerative disease characterized by a …

The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis

RA Cavallaro, A Fuso, F D'Anselmi… - Journal of …, 2006 - content.iospress.com
High homocysteine (Hcy) together with low S-adenosylmethionine (SAM) levels are often
observed in Alzheimer disease (AD), and this could be a sign of alteration of SAM/Hcy …

One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?

A Fuso, S Scarpa - Neurobiology of aging, 2011 - Elsevier
The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a
multifactorial disease; a strong link between nutritional and genetic factors with normal aging …

Alzheimer's disorder: epigenetic connection and associated risk factors

VK Sharma, V Mehta, TG Singh - Current neuropharmacology, 2020 - ingentaconnect.com
The gene based therapeutics and drug targets have shown incredible and appreciable
advances in alleviating human sufferings and complexities. Epigenetics simply means …