Abnormal homocysteine metabolism: an insight of Alzheimer's disease from DNA methylation
T Pi, B Liu, J Shi - Behavioural Neurology, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a chronic neurodegenerative disease in the central nervous
system that has complex pathogenesis in the elderly. The current review focuses on the …
system that has complex pathogenesis in the elderly. The current review focuses on the …
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
Epigenetics in Alzheimer's disease: perspective of DNA methylation
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …
understood, but over the past years, the involvement of epigenetic mechanisms in the …
Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia
M Bednarska-Makaruk, A Graban… - Experimental …, 2016 - Elsevier
Epigenetics (particularly DNA methylation) together with environmental and genetic factors,
are key to understanding the pathogenesis of many diseases including dementia …
are key to understanding the pathogenesis of many diseases including dementia …
Alterations in global DNA methylation and hydroxymethylation are not detected in A lzheimer's disease
Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …
There is evidence for the contribution of environmental factors, whose effect may be …
The role for oxidative stress in aberrant DNA methylation in Alzheimer's disease
J L. Fleming, C J. Phiel… - Current Alzheimer …, 2012 - benthamdirect.com
Alzheimer's disease (AD) is a common, progressive neurodegenerative disorder without
highly effective therapies. The etiology of AD is heterogeneous with amyloid-beta plaques …
highly effective therapies. The etiology of AD is heterogeneous with amyloid-beta plaques …
Epigenetics in Alzheimer's disease: a focus on DNA modifications
N Coppieters, M Dragunow - Current pharmaceutical design, 2011 - ingentaconnect.com
Epigenetic alterations have been associated with several human diseases including
Alzheimer's disease (AD). AD is a complex neurodegenerative disease characterized by a …
Alzheimer's disease (AD). AD is a complex neurodegenerative disease characterized by a …
The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis
RA Cavallaro, A Fuso, F D'Anselmi… - Journal of …, 2006 - content.iospress.com
High homocysteine (Hcy) together with low S-adenosylmethionine (SAM) levels are often
observed in Alzheimer disease (AD), and this could be a sign of alteration of SAM/Hcy …
observed in Alzheimer disease (AD), and this could be a sign of alteration of SAM/Hcy …
One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?
A Fuso, S Scarpa - Neurobiology of aging, 2011 - Elsevier
The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a
multifactorial disease; a strong link between nutritional and genetic factors with normal aging …
multifactorial disease; a strong link between nutritional and genetic factors with normal aging …
Alzheimer's disorder: epigenetic connection and associated risk factors
The gene based therapeutics and drug targets have shown incredible and appreciable
advances in alleviating human sufferings and complexities. Epigenetics simply means …
advances in alleviating human sufferings and complexities. Epigenetics simply means …
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