Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer
M Kulis, AC Queirós, R Beekman… - Biochimica et Biophysica …, 2013 - Elsevier
Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …
fifth base has been extensively studied and debated. Until recently, the majority of DNA …
The diverse roles of DNA methylation in mammalian development and disease
MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
Linking DNA methylation and histone modification: patterns and paradigms
H Cedar, Y Bergman - Nature Reviews Genetics, 2009 - nature.com
Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …
repression during development. Certain forms of histone methylation cause local formation …
DNA methylation: the nuts and bolts of repression
TB Miranda, PA Jones - Journal of cellular physiology, 2007 - Wiley Online Library
DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation can silence genes and repetitive …
organization and gene expression. DNA methylation can silence genes and repetitive …
The role of DNA methylation and histone modifications in transcriptional regulation in humans
JL Miller, PA Grant - Epigenetics: Development and Disease, 2012 - Springer
Although the field of genetics has grown by leaps and bounds within the last decade due to
the completion and availability of the human genome sequence, transcriptional regulation …
the completion and availability of the human genome sequence, transcriptional regulation …
[图书][B] DNA methylation: molecular biology and biological significance
J Jost, H Saluz - 2013 - books.google.com
The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see
first chapter). Recognition of its possible physiologi cal role in eucaryotes was first …
first chapter). Recognition of its possible physiologi cal role in eucaryotes was first …
Controlling DNA methylation: many roads to one modification
Genetic, biochemical and cytological studies on DNA methylation in several eukaryotic
organisms have resulted in leaps of understanding in the past three years. Discoveries of …
organisms have resulted in leaps of understanding in the past three years. Discoveries of …
Reactivating the expression of methylation silenced genes in human cancer
AR Karpf, DA Jones - Oncogene, 2002 - nature.com
DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …
DNA methylation and silencing of gene expression
J Newell-Price, AJL Clark, P King - Trends in Endocrinology & Metabolism, 2000 - cell.com
DNA methylation is associated with the silencing of gene expression. The predominant
mechanism involves the methylation of DNA and the subsequent recruitment of binding …
mechanism involves the methylation of DNA and the subsequent recruitment of binding …
Genomic targeting of methylated DNA: influence of methylation on transcription, replication, chromatin structure, and histone acetylation
D Schübeler, MC Lorincz, DM Cimbora… - … and cellular biology, 2000 - Am Soc Microbiol
We have developed a strategy to introduce in vitro-methylated DNA into defined
chromosomal locations. Using this system, we examined the effects of methylation on …
chromosomal locations. Using this system, we examined the effects of methylation on …