Summary Eukaryotic genomes contain 5-methylcytosine (5mC) as a rare base. 5mC arises
by postsynthetic modification of cytosine and occurs, at least in animals, predominantly in …

A large body of evidence demonstrates that DNA methylation plays a role in gene regulation
in animal cells. Not only is there a correlation between gene transcription and …

Recent advances have expanded our understanding of the processes underlying the
establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes …

There is considerable interest in the role that DNA methylation (5-methylcytosine [5MeC]
content of DNA) plays in both normal development (Razin and Kafri, 1994) and …

Proper establishment and faithful maintenance of epigenetic information is crucial for the
correct development of complex organisms. For mammals, it is now accepted that DNA …

DNA methylation is found almost ubiquitously in nature and the methyltransferases show
evidence of a common evolutionary origin. It will be a fascinating study in protein evolution …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …