Differentiation-related DNA methylation is receiving increasing attention, partly owing to
new, whole-genome analyses. These revealed that cell type-specific differential methylation …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

In mammals, DNA methylation, characterized by the transfer of the methyl group from S-
adenosylmethionines to a base (mainly referred to cytosine), acts as a major epigenetic …

Recent findings suggest that lysine and arginine-specific methylation of histones may
cooperate with other types of post-translational histone modification to regulate chromatin …

DNA methylation plays a pivotal role during development in mammals and is central to
transcriptional silencing. The DNA methyltransferases (DNMTs) are responsible for the …

The mechanisms that establish and maintain methylation patterns in the mammalian
genome are very poorly understood, even though perturbations of methylation patterns lead …

DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …

DNA methylation plays an important role in the regulation of gene expression during
development. Methyl moieties at CpG residues suppress transcription by affecting DNA …

Histone lysine methylation and DNA methylation contribute to transcriptional regulation. We
have previously shown that acetylated histones are associated with unmethylated DNA and …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …