Aberrant DNA methylation is ubiquitous in human cancer and has been shown to occur
early during carcinogenesis, thus providing attractive potential biomarkers for the early …

Cellular DNA undergoes profound changes in methylation during cancer development, with
hypermethylation occurring in specific gene promoters, amidst a backdrop of generalized …

While different markers for cancer diagnosis have been known for at least a decade, the
systematic search for biomarkers emerged only several years ago. In this article, I will …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

Epigenetic alterations are related to inherited but reversible changes in modifications that
regulate gene activity beyond the DNA sequence. DNA methylation is the best characterized …

Cancer arises due to the accumulation of DNA modifications that give cells a selective
growth advantage. One common DNA modification is promoter hypermethylation associated …

DNA methylation is an epigenetic mechanism that plays a key role in regulating gene
expression and other functions. Although this modification is seen in different sequence …

DNA methylation plays an essential role in regulating cell growth and proliferation, and
disease. Changes in aberrant DNA methylation are disease-specific, and, accordingly, the …

DNA methylation is an important and reversible epigenetic modification, which regulates
genomic stability and cellular plasticity. Faithful DNA methylation is essential for mammalian …

Tumor-acquired changes in DNA methylation are the focus of research in an increasing
number of basic, translational, and clinical laboratories around the world. In the laboratory …