Sources of systematic bias in hypercapnia-calibrated functional MRI estimation of oxygen metabolism
The change in cerebral rate of oxidative metabolism (CMRO2) during neural activation may
be estimated from blood oxygenation level-dependent (BOLD) functional magnetic …
be estimated from blood oxygenation level-dependent (BOLD) functional magnetic …
Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
Improved fMRI calibration: precisely controlled hyperoxic versus hypercapnic stimuli
The calibration of functional magnetic resonance imaging (fMRI) for the estimation of
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …
Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism
R Buxton - Frontiers in neuroenergetics, 2010 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is widely used to map patterns of brain
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
Calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain venous oxygen saturation
EK Englund, MA Fernández-Seara… - Journal of Cerebral …, 2020 - journals.sagepub.com
Functional MRI (fMRI) can identify active foci in response to stimuli through BOLD signal
fluctuations, which represent a complex interplay between blood flow and cerebral …
fluctuations, which represent a complex interplay between blood flow and cerebral …
Validation of the hypercapnic calibrated fMRI method using DOT–fMRI fusion imaging
Calibrated functional magnetic resonance imaging (fMRI) is a widely used method to
investigate brain function in terms of physiological quantities such as the cerebral metabolic …
investigate brain function in terms of physiological quantities such as the cerebral metabolic …
CBF/CMRO2 coupling measured with calibrated BOLD fMRI: sources of bias
O Leontiev, DJ Dubowitz, RB Buxton - Neuroimage, 2007 - Elsevier
The coupling between cerebral blood flow (CBF) and cerebral metabolic rate of oxygen
(CMRO2) during brain activation can be characterized by an empirical index n, the ratio of …
(CMRO2) during brain activation can be characterized by an empirical index n, the ratio of …
Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease
JJ Chen, B Uthayakumar… - Journal of Cerebral Blood …, 2022 - journals.sagepub.com
Conventional functional MRI (fMRI) with blood-oxygenation level dependent (BOLD)
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …
[HTML][HTML] Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration
A Merola, K Murphy, AJ Stone, MA Germuska… - Neuroimage, 2016 - Elsevier
Several techniques have been proposed to estimate relative changes in cerebral metabolic
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …