Methylation of DNA plays an important role in the control of gene expression in higher
eukaryotes. This is largely achieved by the packaging of methylated DNA into chromatin …

Eukaryotic DNA methylation is performed by DNA-methyltransferases that catalyze transfer
of a methyl group from S-adenosyl-L-methionine to carbon 5 of cytosine bases in DNA …

DNA methylation is an essential part of the epigenome chromatin modification network,
which also comprises several covalent histone protein post-translational modifications. All …

Methylation patterns are the result of de novo methylation, demethylation, and the
maintenance of existing methylation. Although the existence and identity of an active …

The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …

Cell type-specific DNA methylation patterns are established during mammalian
development and maintained in adult somatic cells. Understanding how these patterns of 5 …

Mammals have long been known to tag their DNA by the addition of methyl groups to
cytosine residues. Only quite recently, however, has the functional significance of DNA …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

Proper DNA methylation patterns are essential for mammalian development and
differentiation. DNA methyltransferases (DNMTs) primarily establish and maintain global …