High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing
DNA methylation stabilizes developmentally programmed gene expression states. Aberrant
methylation is associated with disease progression and is a common feature of cancer …
methylation is associated with disease progression and is a common feature of cancer …
ChAMP: updated methylation analysis pipeline for Illumina BeadChips
Abstract Summary The Illumina Infinium HumanMethylationEPIC BeadChip is the new
platform for high-throughput DNA methylation analysis, effectively doubling the coverage …
platform for high-throughput DNA methylation analysis, effectively doubling the coverage …
DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis
I Rauluseviciute, F Drabløs, MB Rye - Clinical epigenetics, 2019 - Springer
Sequencing technologies have changed not only our approaches to classical genetics, but
also the field of epigenetics. Specific methods allow scientists to identify novel genome-wide …
also the field of epigenetics. Specific methods allow scientists to identify novel genome-wide …
Introduction to single-cell DNA methylation profiling methods
J Ahn, S Heo, J Lee, D Bang - Biomolecules, 2021 - mdpi.com
DNA methylation is an epigenetic mechanism that is related to mammalian cellular
differentiation, gene expression regulation, and disease. In several studies, DNA …
differentiation, gene expression regulation, and disease. In several studies, DNA …
DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning
Recent technological advances have enabled DNA methylation to be assayed at single-cell
resolution. However, current protocols are limited by incomplete CpG coverage and hence …
resolution. However, current protocols are limited by incomplete CpG coverage and hence …
Accurate quantification of DNA methylation using combined bisulfite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform
RM Brena, H Auer, K Kornacker… - Nucleic acids …, 2006 - academic.oup.com
DNA methylation is the best-studied epigenetic modification and describes the conversion of
cytosine to 5-methylcytosine. The importance of this phenomenon is that aberrant promoter …
cytosine to 5-methylcytosine. The importance of this phenomenon is that aberrant promoter …
An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies
K McGregor, S Bernatsky, I Colmegna, M Hudson… - Genome biology, 2016 - Springer
Background Many different methods exist to adjust for variability in cell-type mixture
proportions when analyzing DNA methylation studies. Here we present the result of an …
proportions when analyzing DNA methylation studies. Here we present the result of an …
A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution
Bulk-tissue DNA methylomes represent an average over many different cell types,
hampering our understanding of cell-type-specific contributions to disease development. As …
hampering our understanding of cell-type-specific contributions to disease development. As …
Cytosine methylation profiling of cancer cell lines
DNA-methylation changes in human cancer are complex and vary between the different
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
DMAP: differential methylation analysis package for RRBS and WGBS data
PA Stockwell, A Chatterjee, EJ Rodger… - …, 2014 - academic.oup.com
Motivation: The rapid development of high-throughput sequencing technologies has
enabled epigeneticists to quantify DNA methylation on a massive scale. Progressive …
enabled epigeneticists to quantify DNA methylation on a massive scale. Progressive …