DNA methylation disruption reshapes the hematopoietic differentiation landscape
Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A)
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
[HTML][HTML] Divergent effects of Dnmt3a and Tet2 mutations on hematopoietic progenitor cell fitness
The DNA methylation regulators DNMT3A and TET2 are recurrently mutated in
hematological disorders. Despite possessing antagonistic biochemical activities, loss-of …
hematological disorders. Despite possessing antagonistic biochemical activities, loss-of …
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation
Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
Mutations in the epigenetic modifiers DNMT3A and TET2 non-randomly co-occur in
lymphoma and leukemia despite their epistasis in the methylation–hydroxymethylation …
lymphoma and leukemia despite their epistasis in the methylation–hydroxymethylation …
Comprehensive methylome map of lineage commitment from haematopoietic progenitors
Epigenetic modifications must underlie lineage-specific differentiation as terminally
differentiated cells express tissue-specific genes, but their DNA sequence is unchanged …
differentiated cells express tissue-specific genes, but their DNA sequence is unchanged …
Dnmt3a is essential for hematopoietic stem cell differentiation
Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …
[HTML][HTML] DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
DNA methylation is essential for development and in diverse biological processes. The DNA
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …
A promoter DNA demethylation landscape of human hematopoietic differentiation
V Calvanese, AF Fernández, RG Urdinguio… - Nucleic acids …, 2012 - academic.oup.com
Global mechanisms defining the gene expression programs specific for hematopoiesis are
still not fully understood. Here, we show that promoter DNA demethylation is associated with …
still not fully understood. Here, we show that promoter DNA demethylation is associated with …
Large conserved domains of low DNA methylation maintained by Dnmt3a
Gains and losses in DNA methylation are prominent features of mammalian cell types. To
gain insight into the mechanisms that promote shifts in DNA methylation and contribute to …
gain insight into the mechanisms that promote shifts in DNA methylation and contribute to …
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
AM Bröske, L Vockentanz, S Kharazi, MR Huska… - Nature …, 2009 - nature.com
DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during
differentiation of self-renewing stem cells. However, whether these changes are the cause or …
differentiation of self-renewing stem cells. However, whether these changes are the cause or …