Objective We investigated the pharmacologic properties of midazolam with special regard to
age using the electroencephalogram (EEG) as a measure of the hypnotic‐sedative effect …

The effect of aging on the pharmacodynamics of midazolam was investigated in a double-
blinded study involving 39 consenting patients ranging in age from 39 to 77 yr. Midazolam …

The pharmacokinetics of midazolam, an imidazo-benzodiazepine derivative, have been
studied in 13 subjects over the age of 60 years who received the drug intravenously (0.07 …

The pharmacokinetics of midazolam and 1-hydroxymethylmidazolam were investigated
following oral administration of 7.5, 15 and 30 mg doses of midazolam in solution to 12 …

The first‐dose pharmacokinetics of midazolam and its primary α‐hydroxy metabolite were
studied after single‐dose administration. Eligible study patients were enrolled into one of …

The pharmacokinetics and pharmacodynamics of midazolam and diazepam were compared
after intravenous infusions of 0.03 and 0.07 mg/kg midazolam and 0.1 and 0.2 mg/kg …

Objective To determine whether age‐dependent pharmacokinetic and pharmacodynamic
alterations account for a more pronounced response to benzodiazepines among elderly …

Midazolam is a commonly used sedative in critically ill, mechanically ventilated patients in
intensive care unit (ICU) settings worldwide. We used a nine‐step decision‐making …

Physiological and temporal variation in the disposition of midazolam has been reported. In
order to delineate the underlying mechanisms of these alterations, we infused in 5 healthy …

The effects of age, gender and low‐dose (50 mcg or less) oral contraceptive steroids (OCS)
on the pharmacokinetics of midazolam were evaluated following a single 7.5 mg …