To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a
family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal …

Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

Aims/hypothesis The association between low birthweight (LBW) and risk of developing type
2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target …

Background Monozygotic twins discordant for type 2 diabetes constitute an ideal model to
study environmental contributions to type 2 diabetic traits. We aimed to examine whether …

Lifelong regular physical activity is associated with reduced risk of type 2 diabetes (T2D),
maintenance of muscle mass and increased metabolic capacity. However, little is known …

Aims/hypothesis Energy-dense diets that are high in fat are associated with a risk of
metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as …

DNA methylation is a covalent biochemical modification controlling chromatin structure and
gene expression. Exercise elicits gene expression changes that trigger structural and …

Physical activity is a strong stimulus influencing the overall physiology of the human body.
Exercises lead to biochemical changes in various tissues and exert an impact on gene …

Type 2 diabetes (T2D) develops due to insulin resistance and impaired insulin secretion,
predominantly in genetically predisposed subjects exposed to nongenetic risk factors like …

We integrate comeasured gene expression and DNA methylation (DNAme) in 265 human
skeletal muscle biopsies from the FUSION study with> 7 million genetic variants and eight …