[HTML][HTML] Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements
E Grundberg, E Meduri, JK Sandling… - The American Journal of …, 2013 - cell.com
Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency …
disease susceptibility. However, little is known about the genome-wide frequency …
A longitudinal study of DNA methylation as a potential mediator of age-related diabetes risk
DNA methylation (DNAm) has been found to show robust and widespread age-related
changes across the genome. DNAm profiles from whole blood can be used to predict human …
changes across the genome. DNAm profiles from whole blood can be used to predict human …
[HTML][HTML] Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1,500 older adults
I Florath, K Butterbach, J Heiss, M Bewerunge-Hudler… - Diabetologia, 2016 - Springer
Aims/hypothesis Development of type 2 diabetes depends on environmental and genetic
factors. We investigated the epigenome-wide association of prevalent diabetes with DNA …
factors. We investigated the epigenome-wide association of prevalent diabetes with DNA …
[HTML][HTML] Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …
disease and diabetes. Many smoking-associated signals have been detected in the blood …
Exercise training alters the genomic response to acute exercise in human adipose tissue
Aim: To determine the genomic mechanisms by which adipose tissue responds to acute and
chronic exercise. Methods: We profiled the transcriptomic and epigenetic response to acute …
chronic exercise. Methods: We profiled the transcriptomic and epigenetic response to acute …
DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk
T Dayeh, T Tuomi, P Almgren, A Perfilyev… - Epigenetics, 2016 - Taylor & Francis
Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental
for prevention of the disease. Consequently, it is essential to search for new biomarkers that …
for prevention of the disease. Consequently, it is essential to search for new biomarkers that …
Meta‐analysis of genome‐wide DNA methylation and integrative omics of age in human skeletal muscle
Background Knowledge of age‐related DNA methylation changes in skeletal muscle is
limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a …
limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a …
Epigenome-wide profiling of DNA methylation in paired samples of adipose tissue and blood
Many epigenetic association studies have attempted to identify DNA methylation markers in
blood that are able to mirror those in target tissues. Although some have suggested potential …
blood that are able to mirror those in target tissues. Although some have suggested potential …
Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study
Known genetic susceptibility loci for type 2 diabetes (T2D) explain only a small proportion of
heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation …
heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …