MeCP2 is an essential transcriptional repressor that mediates gene silencing through
binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic …

The neurodevelopmental disorder known as Rett syndrome has recently been linked to the
methyl-CpG-binding transcriptional repressor, MeCP2. In this report we examine the …

Abstract Methylated CpG Binding Protein 2 (MeCP2) is a nuclear protein named for its ability
to selectively recognize methylated DNA. Much attention has been focused on …

We have investigated the properties of mutant forms of the methyl-CpG binding
transcriptional repressor MeCP2 associated with Rett syndrome, a childhood …

Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several
neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the …

DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that repress transcription through recruitment of corepressors that modify chromatin. To …

hMeCP2 (human methylated DNA-binding protein 2), mutations of which cause most cases
of Rett syndrome (RTT), is involved in the transmission of repressive epigenetic signals …

Methylation of DNA is essential for development in the mouse and plays an important role in
inactivation of the X-chromosome, genomic imprinting and gene silencing. The properties of …

Most cases of Rett syndrome (RTT) are caused by mutations in the methylated DNA-binding
protein, MeCP2. Here, we have shown that frequent RTT-causing missense mutations …