Status epilepticus (SE) is an acute, life-threatening medical condition that requires
immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a …

All benzodiazepines enter cerebral tissue rapidly. However, the duration of action is short for
diazepam (< 2 hours) and midazolam (3 to 4 hours) and longer for clonazepam (24 hours) …

Objective Benzodiazepines (BZD) are recommended as first‐line treatment for status
epilepticus (SE), with lorazepam (LZP) and midazolam (MDZ) being the most widely used …

Purpose The aim of this review was to systematically examine safety and efficacy outcomes,
as well as patient/caregiver satisfaction, from clinical studies in pediatric and adult patients …

Purpose Systematic evaluation of published evidence-base of the efficacy of five
antiepileptic drugs–lacosamide, levetiracetam, valproate, phenytoin and phenobarbital–in …

Diazepam rectal gel (Diastat®) is the only FDA-approved product indicated for acute
repetitive seizures. Despite its proven efficacy, most older children and adults object to this …

Convulsive status epilepticus (CSE) is one of the most common pediatric neurological
emergencies. Ongoing seizure activity is a dynamic process and may be associated with …

Aim The aim of this study was to estimate the comparative efficacy and safety of antiepileptic
drugs (AEDs) in adults with benzodiazepine-resistant convulsive status epilepticus (SE) …

Opinion statement Benzodiazepines are commonly prescribed as anxiolytics, sedatives, and
anticonvulsants. They act on the GABA A receptor by increasing the conductance chloride …

INTRODUCTION: The evidence based data to guide management in patients of
benzodiazepine refractory status epilepticus (SE) is still lacking. We conducted a …