Despite thousands of articles about 5-methylcytosine (m5C) residues in vertebrate DNA,
there is still controversy concerning the role of genomic m5C in normal vertebrate …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

The DNA of many organisms contains modified bases such as 5-methylcytosine and 6-
methyladenine, in addition to the four unmodified bases (reviewed by Razin and Szyf …

Methylation of CpG dinucleotides is an epigenetic mechanism involved in the regulation of
gene expression in mammals. The patterns of CpG methylation are specie and tissue …

Methylation of DNA plays an important role in the control of gene expression in higher
eukaryotes. This is largely achieved by the packaging of methylated DNA into chromatin …

Proper establishment and faithful maintenance of epigenetic information is crucial for the
correct development of complex organisms. For mammals, it is now accepted that DNA …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

Epigenetic alterations such as DNA methylation have been implicated in the development
and progression of various cancers. DNA methylation consists of the reversible addition of a …

DNA methylation is a key epigenetic mark when occurring in the promoter and enhancer
regions regulates the accessibility of the binding protein and gene transcription. DNA …