Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to
afford the genome flexibility in responding to developmental and environmental cues in …

Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the methyl-
CpG binding protein gene (MECP2). MeCP2 is a methyl-cytosine binding protein that is …

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several
neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the …

The discovery that Rett syndrome is caused by mutations that affect the methyl-CpG-binding
protein MeCP2 provided a major breakthrough in understanding this severe …

Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the devastating
neurodevelopmental disorder Rett syndrome. It has been challenging to understand how …

The genomes of mammalian neurons contain uniquely high levels of non-CG DNA
methylation that can be bound by the Rett syndrome protein, MeCP2, to regulate gene …

DNA methylation is implicated in neuronal biology via the protein MeCP2, the mutation of
which causes Rett syndrome. MeCP2 recruits the NCOR1/2 co-repressor complexes to …

INTRODUCTION Rett syndrome is a severe neurodevelopmental disorder that is mainly
caused by mutations in the methyl-CpG-binding protein 2 gene (MeCP2). Initially, MeCP2 …

Mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) lead to disrupted
neuronal function and can cause the neurodevelopmental disorder Rett syndrome. MeCP2 …