Male infertility is a complex, multifactorial, and heterogeneous condition. In 15% of couples,
infertility results from an identifiable genetic defect. However, in 40% of couples, male …

Objective To study peripheral blood DNA differential methylation in oligozoospermic infertile
men in comparison with normozoospermic fertile controls. Design Case-control study …

Background Several independent research groups have shown that alterations in human
sperm methylation profiles correlate with decreased fecundity and an increased risk of poor …

Recent studies have shown significant associations of aberrant DNA methylation in
spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions …

Editorial Comment: DNA methylation is a fundamental way of regulating gene expression,
providing on and off switches that are part of a system that allows for an eye and a liver cell …

Abstract Infertility affects 10–15% of couples, and approximately 50% of cases are linked to
male factor infertility. The purpose of this study was to evaluate the DNA methylation patterns …

Objective To investigate the power of DNA methylation variability in sperm cells in assessing
male fertility potential. Design Retrospective cohort. Setting Fertility care centers. Patients …

OBJECTIVE: To assess reliability of a high-throughput assay of sperm DNA methylation.
DESIGN: Observational study comparing DNA methylation of sperm isolated from 3 divided …

The review published by Kläver and Gromoll1 is a timely reminder of the ever-changing
landscape of the clinical andrology laboratory as well as the limitations of current …

Numerous recent studies have examined the impact epigenetics—including DNA
methylation—has on spermatogenesis and male infertility. Differential methylation of several …