The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity

S Müller, M Sicorello, D Moser, L Frach… - Translational …, 2023 - nature.com
The oxytocin receptor gene (OXTR) is of interest when investigating the effects of early
adversity on DNA methylation. However, there is heterogeneity regarding the selection of …

The DNA methylation landscape of the human oxytocin receptor gene (OXTR): Recommendations for future research

S Müller, M Sicorello, D Moser, L Frach, A Limberg… - bioRxiv, 2022 - biorxiv.org
The oxytocin receptor gene (OXTR) is of interest when investigating the effects of early
adversity on DNA methylation. However, there is heterogeneity regarding the selection of …

Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother–newborn dyads

L Ramo-Fernández, AM Gumpp, C Boeck… - Translational …, 2021 - nature.com
The neuropeptide oxytocin (OXT) and its receptor (OXTR) modulate interpersonal
relationships, particularly mother–child interactions. DNA methylation (DNAm) changes of …

Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

JP Gouin, QQ Zhou, L Booij, M Boivin, SM Côté… - Scientific Reports, 2017 - nature.com
Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as
a molecular mechanism underlying the increased risk of mental disorder associated with …

Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress

I Milaniak, CAM Cecil, ED Barker, CL Relton… - Development and …, 2017 - cambridge.org
Emerging research in epigenetics has shown that there is variability in how environmental
exposures “get under the skin” through mechanisms like DNA methylation to influence gene …

Sex-dependent association between variability in infants' OXTR methylation at birth and negative affectivity at 3 months

S Nazzari, S Grumi, M Villa, F Mambretti… - …, 2022 - Elsevier
Background Sex-specific differences in DNA methylation of the oxytocin receptor gene
(OXTR) have been shown in adults and are related to several mental disorders. Negative …

Perinatal depression and DNA methylation of oxytocin-related genes: a study of mothers and their children

L King, S Robins, G Chen, V Yerko, Y Zhou… - Hormones and …, 2017 - Elsevier
The present study investigated the association of perinatal depression (PD) with differential
methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin …

Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

JS Danoff, KL Wroblewski, AJ Graves, GC Quinn… - Clinical …, 2021 - Springer
Background The neuropeptide oxytocin regulates mammalian social behavior. Disruptions
in oxytocin signaling are a feature of many psychopathologies. One commonly studied …

The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

C Maud, J Ryan, JE McIntosh, CA Olsson - BMC psychiatry, 2018 - Springer
Abstract Background The neuropeptide Oxytocin (OXT) plays a central role in birthing,
mother-infant bonding and a broad range of related social behaviours in mammals. More …

Oxytocin receptor genetic and epigenetic variations: association with child abuse and adult psychiatric symptoms

EL Smearman, LM Almli, KN Conneely… - Child …, 2016 - Wiley Online Library
Childhood abuse can alter biological systems and increase risk for adult psychopathology.
Epigenetic mechanisms, alterations in DNA structure that regulate the gene expression, are …