[HTML][HTML] Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

EJ Kraaijenvanger, Y He, H Spencer, AK Smith… - Neuroscience & …, 2019 - Elsevier
The human oxytocin (OXT) system is implicated in the regulation of complex social
behaviors, as well as in psychopathologies characterized by social deficits. Emerging …

Oxytocin receptor gene methylation as a molecular marker for severity of depressive symptoms in affective disorder patients

B Ludwig, L Carlberg, K Kienesberger, P Swoboda… - BMC psychiatry, 2022 - Springer
Background Oxytocin (OXT) is a neuropeptide and hormone involved in emotional
functioning and also seems to play a role in moderating the stress response. Both preclinical …

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness

P Toepfer, KJ O'Donnell, S Entringer, E Garg… - …, 2019 - Elsevier
Maternal behavior (MB) is observable across mammals and represents an important feature
of environmental variation during early postnatal development. Oxytocin (OT) plays a crucial …

Methylation of the oxytocin receptor gene in clinically depressed patients compared to controls: The role of OXTR rs53576 genotype

I Reiner, MH Van IJzendoorn… - Journal of psychiatric …, 2015 - Elsevier
The emerging field of epigenetics provides a biological basis for gene-environment
interactions relevant to depression. We focus on DNA methylation of exon 1 and 2 of the …

DNA methylation of the oxytocin receptor across neurodevelopmental disorders

MT Siu, SJ Goodman, I Yellan, DT Butcher… - Journal of autism and …, 2021 - Springer
Many neurodevelopmental disorders (NDDs) share common learning and behavioural
impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we …

Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience

R Kumsta, E Hummel, FS Chen… - Frontiers in …, 2013 - frontiersin.org
Genetic approaches have improved our understanding of the neurobiological basis of social
behavior and cognition. For instance, common polymorphisms of genes involved in oxytocin …

Epigenetic modification of the oxytocin receptor gene: implications for autism symptom severity and brain functional connectivity

E Andari, S Nishitani, G Kaundinya… - …, 2020 - nature.com
The role of oxytocin in social cognition has attracted tremendous interest in social
neuroscience and psychiatry. Some studies have reported improvement in social symptoms …

Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats

AK Beery, LM McEwen, JL MacIsaac, DD Francis… - Hormones and …, 2016 - Elsevier
This article is part of a Special Issue “Parental Care”. Since the first report of maternal care
effects on DNA methylation in rats, epigenetic modifications of the genome in response to …

Oxytocin receptor exon III methylation in the umbilical cord blood of newborns with prenatal exposure to crack cocaine

T Baptista, LA de Azeredo, A Zaparte… - Frontiers in Cell and …, 2021 - frontiersin.org
Background Prenatal cocaine exposure (PCE) is associated with behavioral, cognitive, and
social consequences in children that might persist into later development. However, there …

DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology

K Lancaster, L Goldbeck, MH Puglia… - Social cognitive and …, 2018 - academic.oup.com
Oxytocin has anxiolytic properties whose mechanisms of action are still being identified.
DNA methylation in the promoter region of the oxytocin receptor gene (OXTR), an epigenetic …