Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder

SK Siecinski, SN Giamberardino, M Spanos… - Autism …, 2023 - Wiley Online Library
Abstract Oxytocin (OT), the brain's most abundant neuropeptide, plays an important role in
social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum …

Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls

RJ Thompson, KJ Parker, JF Hallmayer… - …, 2011 - Elsevier
The nonapeptide oxytocin and its receptor have been implicated in the regulation of
mammalian social behavior and stress physiology. Evidence is accumulating that the quality …

Oxytocin receptor expression patterns in the human brain across development

J Rokicki, T Kaufmann, AMG De Lange… - …, 2022 - nature.com
Oxytocin plays a vital role in social behavior and homeostatic processes, with animal models
indicating that oxytocin receptor (OXTR) expression patterns in the brain influence behavior …

Oxytocin receptor gene DNA methylation: a biomarker of treatment response in obsessive-compulsive disorder?

MA Schiele, C Thiel, L Kollert, L Fürst… - Psychotherapy and …, 2020 - karger.com
Introduction: Obsessive-compulsive disorder (OCD) is associated with high chronicity and
treatment resistance, indicating the need for early therapy response markers enabling fast …

The altered promoter methylation of oxytocin receptor gene in autism

M Elagoz Yuksel, B Yuceturk, OF Karatas… - Journal of …, 2016 - Taylor & Francis
Autism spectrum disorder (ASD) is one of the lifelong existing disorders. Abnormal
methylation status of gene promoters of oxytonergic system has been implicated as among …

Oxytocin pathway genes: evolutionary ancient system impacting on human affiliation, sociality, and psychopathology

R Feldman, M Monakhov, M Pratt, RP Ebstein - Biological psychiatry, 2016 - Elsevier
Oxytocin (OT), a nonapeptide signaling molecule originating from an ancestral peptide,
appears in different variants across all vertebrate and several invertebrate species …

Neuroimaging genetics of oxytocin: A transcriptomics-informed systematic review

D Prata, M Silva - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
The last couple of decades have witnessed a rapid accumulation of studies implicating
oxytocin (OT) in several neurobiological underpinnings of human behaviour and their …

Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques

D De Leon, S Nishitani, H Walum, KM McCormack… - Hormones and …, 2020 - Elsevier
Oxytocin (OXT) and its receptor (OXTR) are encoded by OXT and OXTR, respectively.
Variable methylation of these genes has been linked to variability in sociability and …

Association between the oxytocin receptor (OXTR) gene and children's social cognition at 18 months

M Wade, TJ Hoffmann, K Wigg… - Genes, Brain and …, 2014 - Wiley Online Library
At 18 months, children engage in a variety of social behaviors that reflect their nascent ability
to understand the intentions of other people (eg joint attention, empathy, cooperation and …

Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders

I Cataldo, A Azhari, B Lepri, G Esposito - Research in developmental …, 2018 - Elsevier
Oxytocin plays an important role in the modulation of social behavior in both typical and
atypical contexts. Also, the quality of early parental care sets the foundation for long-term …