The Methylation of Clock Genes in Perinatal Depression: Which Role for Oxytocin?

S Iodice, M Di Paolo, JL Barkin, L Tarantini… - Frontiers in …, 2021 - frontiersin.org
Background: Perinatal Depression (PD) is a widespread disabling condition that is
hypothesized to be associated with abnormalities in circadian rhythms and neuropeptide …

A role of oxytocin receptor gene brain tissue expression quantitative trait locus rs237895 in the intergenerational transmission of the effects of maternal childhood …

P Toepfer, KJ O'Donnell, S Entringer, CM Heim… - Journal of the American …, 2019 - Elsevier
Objective Women exposed to childhood maltreatment (CM) are more likely to exhibit
insensitive parenting, which may have consequences for their offspring's development …

A multi-modal MRI analysis of brain structure and function in relation to OXT methylation in maltreated children and adolescents

S Nishitani, TX Fujisawa, D Hiraoka, K Makita… - Translational …, 2021 - nature.com
Child maltreatment dysregulates the brain's oxytocinergic system, resulting in dysfunctional
attachment patterns. However, how the oxytocinergic system in children who are maltreated …

Epigenetic dynamics in infancy and the impact of maternal engagement

KM Krol, RG Moulder, TS Lillard, T Grossmann… - Science …, 2019 - science.org
The contribution of nature versus nurture to the development of human behavior has been
debated for centuries. Here, we offer a piece to this complex puzzle by identifying the human …

Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress

AJ Myers, L Williams, JM Gatt, EZ McAuley-Clark… - Journal of psychiatric …, 2014 - Elsevier
Background Oxytocin is a neuropeptide that is involved in the regulation of mood, anxiety
and social biology. Genetic variation in the oxytocin receptor gene (OXTR) has been …

Maternal oxytocin treatment at birth increases epigenetic age in male offspring

JS Danoff, CS Carter, J Gordevičius… - Developmental …, 2024 - Wiley Online Library
Exogenous oxytocin is widely used to induce or augment labor with little understanding of
the impact on offspring development. In rodent models, including the prairie vole (Microtus …

The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene

MS Tollenaar, ML Molendijk, BWJH Penninx… - European archives of …, 2017 - Springer
Background The oxytocin receptor (OXTR) gene may be involved in resilience or
vulnerability towards stress, and hence in the development of stress-related disorders. There …

Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain

MH Puglia, TS Lillard, JP Morris… - Proceedings of the …, 2015 - National Acad Sciences
In humans, the neuropeptide oxytocin plays a critical role in social and emotional behavior.
The actions of this molecule are dependent on a protein that acts as its receptor, which is …

Genetic imaging of the association of oxytocin receptor gene (OXTR) polymorphisms with positive maternal parenting

KJ Michalska, J Decety, C Liu, Q Chen… - Frontiers in behavioral …, 2014 - frontiersin.org
Background: Well-validated models of maternal behavior in small-brain mammals posit a
central role of oxytocin in parenting, by reducing stress and enhancing the reward value of …

DNA methylation at the neonatal state and at the time of diagnosis: preliminary support for an association with the estrogen receptor 1, gamma-aminobutyric acid B …

JB Nissen, CS Hansen, A Starnawska… - Frontiers in …, 2016 - frontiersin.org
Obsessive–compulsive disorder (OCD) is a neuropsychiatric disorder. Non-genetic factors
and their interaction with genes have attracted increasing attention. Epigenetics is regarded …