While different markers for cancer diagnosis have been known for at least a decade, the
systematic search for biomarkers emerged only several years ago. In this article, I will …

Epigenetic alterations are related to inherited but reversible changes in modifications that
regulate gene activity beyond the DNA sequence. DNA methylation is the best characterized …

Cellular DNA undergoes profound changes in methylation during cancer development, with
hypermethylation occurring in specific gene promoters, amidst a backdrop of generalized …

Aberrant DNA methylation is ubiquitous in human cancer and has been shown to occur
early during carcinogenesis, thus providing attractive potential biomarkers for the early …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …

DNA methylation is the best-studied epigenetic modification and altered DNA methylation
patterns have been identified in cancer and many other complex diseases. The first DNA …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

DNA methylation plays an essential role in regulating cell growth and proliferation, and
disease. Changes in aberrant DNA methylation are disease-specific, and, accordingly, the …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …