DNA methylation is a mechanism of epigenetic regulation that is common to all vertebrates.
Functional studies underscore its relevance for tissue homeostasis, but the global dynamics …

A fundamental initiative for evolutionary biologists is to understand the molecular basis
underlying phenotypic diversity. A long-standing hypothesis states that species-specific traits …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

CG methylation is an epigenetically inherited chemical modification of DNA found in plants
and animals. In mammals it is essential for accurate regulation of gene expression and …

In mammals the genome is shaped by epigenetic regulation to manifest numerous cellular
identities. The term epigenetics has been used to refer to changes in gene expression …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …