Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …

DNA methylation is an essential epigenetic mark that is required for normal development.
Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment …

Epigenetic changes are heritable modifications that do not involve alterations in the primary
DNA sequence. They regulate crucial cellular functions such as genome stability, X …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

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