Dynamic epigenetic reprogramming occurs during mammalian germ cell development,
although the targets of this process, including DNA demethylation and de novo methylation …

Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …

Background A growing body of evidence suggests that certain epiphenotypes can be
passed across generations via both the male and female germlines of mammals. These …

Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …

Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …

Germline cells reprogramme extensive epigenetic modifications to ensure the cellular
totipotency of subsequent generations and to prevent the accumulation of epimutations …

Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

Global DNA demethylation in humans is a fundamental process that occurs in pre-
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …