High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice
H Kobayashi, T Sakurai, F Miura, M Imai… - Genome …, 2013 - genome.cshlp.org
Dynamic epigenetic reprogramming occurs during mammalian germ cell development,
although the targets of this process, including DNA demethylation and de novo methylation …
although the targets of this process, including DNA demethylation and de novo methylation …
Global profiling of DNA methylation erasure in mouse primordial germ cells
S Guibert, T Forné, M Weber - Genome research, 2012 - genome.cshlp.org
Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …
[HTML][HTML] Protection from DNA re-methylation by transcription factors in primordial germ cells and pre-implantation embryos can explain trans-generational epigenetic …
I Kremsky, VG Corces - Genome biology, 2020 - Springer
Background A growing body of evidence suggests that certain epiphenotypes can be
passed across generations via both the male and female germlines of mammals. These …
passed across generations via both the male and female germlines of mammals. These …
[HTML][HTML] The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway
P Hajkova, SJ Jeffries, C Lee, N Miller, SP Jackson… - Science, 2010 - science.org
Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …
A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells
R Ohno, M Nakayama, C Naruse, N Okashita… - …, 2013 - journals.biologists.com
Germline cells reprogramme extensive epigenetic modifications to ensure the cellular
totipotency of subsequent generations and to prevent the accumulation of epimutations …
totipotency of subsequent generations and to prevent the accumulation of epimutations …
[HTML][HTML] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks
H Kobayashi, T Sakurai, M Imai, N Takahashi… - PLoS …, 2012 - journals.plos.org
Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution …
development and genomic imprinting in mammals. Here, we report single-base resolution …
[HTML][HTML] Epigenetic reprogramming in mouse primordial germ cells
Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …
embryos, plays a crucial role in regulating genome functions at critical stages of …
[HTML][HTML] DNA demethylation dynamics in the human prenatal germline
Global DNA demethylation in humans is a fundamental process that occurs in pre-
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …
[HTML][HTML] Genome-wide analysis of DNA methylation dynamics during early human development
H Okae, H Chiba, H Hiura, H Hamada, A Sato… - PLoS …, 2014 - journals.plos.org
DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …
development, which is critical for normal development. Recent reduced representation …