Epigenetic silencing involving the aberrant methylation of promoter region CpG islands is
widely recognized as a tumor suppressor silencing mechanism in cancer. However, the …

Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is
one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of …

CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …

Aberrant CpG island methylation is associated with transcriptional silencing of regulatory
genes in human cancer. Although most CpG islands remain unmethylated, a subset accrues …

Methylation of a CpG island is a faithful marker of silencing of its associated gene. Different
approaches report the methylation status of a CpG island based on the determination of one …

CpG islands are associated with at least half of all cellular genes and are normally
methylation-free. Dense methylation of cytosine residues within islands causes strong and …

CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …

The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …

The epigenetic landscape of cancer includes both focal hypermethylation and broader
hypomethylation in a genome-wide manner. By means of a comprehensive genomic …

Knudson's two-hit hypothesis postulates that genetic alterations in both alleles are required
for the inactivation of tumor-suppressor genes. Genetic alterations include small or large …