Background Epigenetics is the study of processes—beyond DNA sequence alteration—
producing heritable characteristics. For example, DNA methylation modifies gene …

Physical exercise induces adaptive changes leading to a muscle phenotype with enhanced
performance. We first investigated whether genetic polymorphisms altering enzymes …

Lifelong regular physical activity is associated with reduced risk of type 2 diabetes (T2D),
maintenance of muscle mass and increased metabolic capacity. However, little is known …

Essential hypertension is the leading preventable cause of death in the world.
Epidemiological studies have shown that physical training can reduce blood pressure (BP) …

Physical exercise has proven cardiovascular benefits, yet there is no clear understanding of
the related molecular mechanisms leading to this. Here we determined the beneficial …

Lifestyle interventions, including exercise and dietary supplementation, can modify DNA
methylation and exert health benefits; however, the underlying mechanisms are poorly …

It is well established that physical exercise modulates the function of many physiological
systems, such as the musculoskeletal, the cardiovascular and the nervous system, by …

The vulnerability of epigenetic marks of brain cells to environmental stimuli and its
implication for health have been recently debated. Thus, we used the rat model of acute …

Human aging is accompanied by a decline in muscle mass and muscle function, which is
commonly referred to as sarcopenia. Sarcopenia is associated with detrimental clinical …

Background Studies demonstrate the impact of diet and physical activity on epigenetic
biomarkers, specifically DNA methylation. However, no intervention studies have examined …