Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages

A Hansakon, P Mutthakalin, P Ngamskulrungroj… - Virulence, 2019 - Taylor & Francis
Cryptococcus-macrophage interaction is crucial in the development of cryptococcocal
diseases. C. neoformans and C. gattii are major pathogenic species that occupy different …

Dynamic virulence: real-time assessment of intracellular pathogenesis links Cryptococcus neoformans phenotype with clinical outcome

MK Mansour, JM Vyas, SM Levitz - MBio, 2011 - Am Soc Microbiol
While a myriad of studies have examined host factors that predispose persons to infection
with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has …

Cryptococcus gattii Induces a Cytokine Pattern That Is Distinct from Other Cryptococcal Species

T Schoffelen, MT Illnait-Zaragozi, LAB Joosten… - PloS one, 2013 - journals.plos.org
Understanding more about the host's immune response to different Cryptococcus spp. will
provide additional insight into the pathogenesis of cryptocococcis. We hypothesized that the …

A Sensitive High-Throughput Assay for Evaluating Host-Pathogen Interactions in Cryptococcus neoformans Infection

D Srikanta, M Yang, M Williams, TL Doering - PLoS One, 2011 - journals.plos.org
Background Cryptococcus neoformans causes serious disease in immunocompromised
individuals, leading to over 600,000 deaths per year worldwide. Part of this impact is due to …

Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus …

PY Cheng, A Sham, JW Kronstad - Infection and immunity, 2009 - Am Soc Microbiol
The fungal pathogen Cryptococcus neoformans causes approximately one million cases of
cryptococcosis per year in people with AIDS. In contrast, the related species C. gattii is …

Adaptive Immunity to Cryptococcus neoformans Infections

L Mukaremera, K Nielsen - Journal of fungi, 2017 - mdpi.com
The Cryptococcus neoformans/Cryptococcus gattii species complex is a group of fungal
pathogens with different phenotypic and genotypic diversity that cause disease in …

Cryptococcus neoformans and Cryptococcus gattii genes preferentially expressed during rat macrophage infection

L Goulart, LKRE Silva, L Chiapello, C Silveira… - Medical …, 2010 - academic.oup.com
Cryptococcus neoformans and Cryptococcus gattii are encapsulated yeast agents of
cryptococcosis and facultative intracellular pathogens. The interaction of these yeasts with …

Cryptococcus: History, Epidemiology and Immune Evasion

I Diniz-Lima, LM Fonseca, EB Silva-Junior… - Applied Sciences, 2022 - mdpi.com
Cryptococcosis is a disease caused by the pathogenic fungi Cryptococcus neoformans and
Cryptococcus gattii, both environmental fungi that cause severe pneumonia and may even …

Mechanisms of Cryptococcus neoformans-Mediated Host Damage

A Casadevall, C Coelho, A Alanio - Frontiers in immunology, 2018 - frontiersin.org
Cryptococcus neoformans is not usually considered a cytotoxic fungal pathogen but there is
considerable evidence that this microbe can damage host cells and tissues. In this essay …

Pathogenesis of Cryptococcus neoformans

EE McClelland, A Casadevall, HC Eisenman - New insights in medical …, 2007 - Springer
Cryptococcus neoformans (Cn) is a fungal pathogen, commonly found in urban
environments (Tampieri, 2006) that primarily affects immunocompromised individuals …