Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to
orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid …

Objective Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor
expressed in tissues with high oxidative activity that plays a central role in metabolism. In …

Peroxisome proliferator‐activated receptor (PPAR) γ is a nuclear receptor central to glucose
and lipid homeostasis. PPARγ role in nonalcoholic fatty liver disease is controversial …

Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model …

The leading cause of death in patients with nonalcoholic fatty liver disease (NAFLD) is
cardiovascular disease (CVD). However, the mechanisms are unknown. Mice deficient in …

Background & Aims Nonalcoholic steatohepatitis (NASH) is commonly observed in patients
with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for …

Simple Summary In the context of liver disease, one of the more growing public health
problems is the transition from simple steatosis to non-alcoholic steatohepatitis. Profound …

Lately, the world has faced tremendous progress in the understanding of non-alcoholic fatty
liver disease (NAFLD) pathogenesis due to rising obesity rates. Peroxisome proliferator …

Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increasing prevalence
due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health …

Emerging evidence suggests that the lack of PPARα enhances hepatic steatosis and
inflammation in Ppara-null mice when fed a high-fat diet (HFD). Thus, the aim of this study …