Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

The form that an animal takes during development is directed by gene regulatory networks
(GRNs). Developmental GRNs interpret maternally deposited molecules and externally …

Transcription initiation is a key regulatory step in the control of gene expression. Formation
of a preinitiation complex at the right time and at the right promoter is a prerequisite to …

Regulatory elements (enhancers) that are remote from promoters play a critical role in the
spatial, temporal, and physiological control of gene expression. Studies on specific loci …

A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …

Enhancers are important genomic regulatory elements directing cell type-specific
transcription. They assume a key role during development and disease, and their …

Core promoters are minimal regions sufficient to direct accurate initiation of transcription and
are crucial for regulation of gene expression. They are highly diverse in terms of associated …

There has been a recent surge in the use of genome-wide methodologies to identify and
annotate the transcriptional regulatory elements in the human genome. Here we review …

One of the most important questions in biology is how transcription factors (TFs) and
cofactors control enhancer function and thus gene expression. Enhancer activation usually …

Gene expression is precisely controlled in time and space through the integration of signals
that act at gene promoters and gene-distal enhancers. Classically, promoters and …