Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort

TR Franklin, Z Wang, Y Li, JJ Suh, M Goldman… - Addiction …, 2011 - Wiley Online Library
Previously we demonstrated profound effects of dopamine transporter (DAT) SLC6A3
genotype on limbic responses to smoking cues (SCs). Probands carrying at least one copy …

Reward sensitivity of ACC as an intermediate phenotype between DRD4-521T and substance misuse

TE Baker, T Stockwell, G Barnes… - Journal of cognitive …, 2016 - direct.mit.edu
The development and expression of the midbrain dopamine system is determined in part by
genetic factors that vary across individuals such that dopamine-related genes are partly …

Cocaine self-administration produces long-lasting alterations in dopamine transporter responses to cocaine

CA Siciliano, SC Fordahl, SR Jones - Journal of Neuroscience, 2016 - Soc Neuroscience
Cocaine addiction is a debilitating neuropsychiatric disorder characterized by uncontrolled
cocaine intake, which is thought to be driven, at least in part, by cocaine-induced deficits in …

[HTML][HTML] DAT genotype modulates brain and behavioral responses elicited by cigarette cues

TR Franklin, FW Lohoff, Z Wang, N Sciortino… - …, 2009 - nature.com
We previously demonstrated differential activation of the mesocorticolimbic reward circuitry
in response to cigarette cues independent of withdrawal. Despite robust effects, we noted …

Gene–environment interaction in problematic substance use: interaction between DRD4 and insecure attachments

CA Olsson, RK Moyzis, E Williamson, JA Ellis… - Addiction …, 2013 - Wiley Online Library
To investigate the combined effect of an exon III variable number tandem repeat in the
dopamine receptor gene (DRD4) and insecure attachment style on risk for tobacco …

One hour, but not six hours, of daily access to self-administered cocaine results in elevated levels of the dopamine transporter

O Ben-Shahar, JM Moscarello, A Ettenberg - Brain research, 2006 - Elsevier
We have previously shown that brief (1 h) and extended (6 h) daily access to IV cocaine self-
administration produce different behavioral and neural consequences following 2 weeks of …

Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation

TEH Moses, M Burmeister, MK Greenwald - Addiction biology, 2020 - Wiley Online Library
Background Dopamine D1 receptors (encoded by DRD1) are implicated in drug addiction
and high‐risk behaviors. Delay discounting (DD) procedures measure decisional balance …

Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic …

SJ Kohut, T Hiranita, SK Hong, AL Ebbs, V Tronci… - Biological …, 2014 - Elsevier
Background Subjective effects of cocaine are mediated primarily by dopamine (DA)
transporter (DAT) blockade. The present study assessed the hypothesis that different DAT …

The dopamine transporter expression level differentially affects responses to cocaine and amphetamine

B Cagniard, TD Sotnikova, RR Gainetdinov… - Journal of …, 2014 - Taylor & Francis
Although both cocaine and amphetamine mainly target the dopamine transporter (DAT) and
cause psychomotor effects, they have very different mechanisms of actions. The authors …

Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene

RR Wetherill, K Jagannathan, FW Lohoff… - Addiction …, 2014 - Wiley Online Library
Cigarette‐dependent smokers automatically and involuntarily orient attention toward
smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to …