Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort
TR Franklin, Z Wang, Y Li, JJ Suh, M Goldman… - Addiction …, 2011 - Wiley Online Library
Previously we demonstrated profound effects of dopamine transporter (DAT) SLC6A3
genotype on limbic responses to smoking cues (SCs). Probands carrying at least one copy …
genotype on limbic responses to smoking cues (SCs). Probands carrying at least one copy …
Reward sensitivity of ACC as an intermediate phenotype between DRD4-521T and substance misuse
The development and expression of the midbrain dopamine system is determined in part by
genetic factors that vary across individuals such that dopamine-related genes are partly …
genetic factors that vary across individuals such that dopamine-related genes are partly …
Cocaine self-administration produces long-lasting alterations in dopamine transporter responses to cocaine
Cocaine addiction is a debilitating neuropsychiatric disorder characterized by uncontrolled
cocaine intake, which is thought to be driven, at least in part, by cocaine-induced deficits in …
cocaine intake, which is thought to be driven, at least in part, by cocaine-induced deficits in …
[HTML][HTML] DAT genotype modulates brain and behavioral responses elicited by cigarette cues
TR Franklin, FW Lohoff, Z Wang, N Sciortino… - …, 2009 - nature.com
We previously demonstrated differential activation of the mesocorticolimbic reward circuitry
in response to cigarette cues independent of withdrawal. Despite robust effects, we noted …
in response to cigarette cues independent of withdrawal. Despite robust effects, we noted …
Gene–environment interaction in problematic substance use: interaction between DRD4 and insecure attachments
To investigate the combined effect of an exon III variable number tandem repeat in the
dopamine receptor gene (DRD4) and insecure attachment style on risk for tobacco …
dopamine receptor gene (DRD4) and insecure attachment style on risk for tobacco …
One hour, but not six hours, of daily access to self-administered cocaine results in elevated levels of the dopamine transporter
We have previously shown that brief (1 h) and extended (6 h) daily access to IV cocaine self-
administration produce different behavioral and neural consequences following 2 weeks of …
administration produce different behavioral and neural consequences following 2 weeks of …
Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation
Background Dopamine D1 receptors (encoded by DRD1) are implicated in drug addiction
and high‐risk behaviors. Delay discounting (DD) procedures measure decisional balance …
and high‐risk behaviors. Delay discounting (DD) procedures measure decisional balance …
Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic …
SJ Kohut, T Hiranita, SK Hong, AL Ebbs, V Tronci… - Biological …, 2014 - Elsevier
Background Subjective effects of cocaine are mediated primarily by dopamine (DA)
transporter (DAT) blockade. The present study assessed the hypothesis that different DAT …
transporter (DAT) blockade. The present study assessed the hypothesis that different DAT …
The dopamine transporter expression level differentially affects responses to cocaine and amphetamine
B Cagniard, TD Sotnikova, RR Gainetdinov… - Journal of …, 2014 - Taylor & Francis
Although both cocaine and amphetamine mainly target the dopamine transporter (DAT) and
cause psychomotor effects, they have very different mechanisms of actions. The authors …
cause psychomotor effects, they have very different mechanisms of actions. The authors …
Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene
RR Wetherill, K Jagannathan, FW Lohoff… - Addiction …, 2014 - Wiley Online Library
Cigarette‐dependent smokers automatically and involuntarily orient attention toward
smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to …
smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to …