Dopamine signaling in nucleus accumbens is essential for cocaine reward. Interestingly,
imaging studies have reported blunted dopamine increases in striatum (assessed as …

Relapse to drug use is one of the major challenges in treating substance use disorders.
Exposure to drug-related cues and contexts triggers drug craving, which drives cocaine …

Dopamine is critically important in the neural manifestation of motivated behavior, and
alterations in the human dopaminergic system have been implicated in the etiology of …

Animal models of drug use have investigated possible mechanisms governing human
substance use traits for over 100 years. Most cross‐species research on drug use/addiction …

Cocaine, through its activation of dopamine (DA) signaling, usurps pathways that process
natural rewards. However, the extent to which there is overlap between the networks that …

Although traditional sensitization paradigms, which result in an augmentation of cocaine-
induced locomotor behavior and dopamine (DA) overflow following repeated experimenter …

Adolescents are highly vulnerable to addiction and are four times more likely to become
addicted at first exposure than at any other age. The dopamine D1 receptor, which is …

Introduction Locomotor sensitization, defined as the progressive and enduring enhancement
of the motor stimulant effects elicited by repeated exposure to drugs of abuse, is the …

This chapter will summarize genetics findings derived from various strategies and highlight
important neural markers (or correlates) in some specific and extensively studied genes …

Altered activity of the human dopamine transporter gene (hDAT) is associated with several
common and severe brain disorders, including cocaine abuse. However, there is little a …