Eukaryotic genomes contain numerous non-functional high-affinity sequences for
transcription factors. These sequences potentially serve as natural decoys that sequester …

MeCP2, a methyl-CpG binding domain (MBD) protein, is known to bind to methylated CpG
sites via a conserved MBD, leading to transcriptional repression. However, studies in cell …

CpG islands (CGIs) are regions enriched in the dinucleotide CpG; they constitute the
promoter of about 60% of mammalian genes. In cancer cells, some promoter‐associated …

The inducible transcription factor Egr-1 binds specifically to 9-bp target sequences
containing two CpG sites that can potentially be methylated at four cytosine bases. Although …

MeCP2 is a nuclear protein that binds to sites of cytosine methylation in the genome. While
most evidence confirms this epigenetic mark as the primary determinant of DNA binding …

DNA methylation is an epigenetic modification that is implicated in transcriptional silencing.
It is becoming increasingly clear that both correct levels and proper interpretation of DNA …

CG methylation is an epigenetically inherited chemical modification of DNA found in plants
and animals. In mammals it is essential for accurate regulation of gene expression and …

DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic
repressor of transcription. Because DNA methylation is reversible, there is much interest in …

ABSTRACT DNA methylation on CpGs regulates transcription in mammals, both by
decreasing the binding of methylation-repelled factors and by increasing the binding of …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …