Aberrant methylation of CpG islands in promoter regions of tumor cells is one of the major
mechanisms for silencing of tumor suppressor genes. We determined the frequency of …

Aberrant methylation of CpG islands acquired in tumor cells in promoter regions is one
method for loss of gene function. We determined the frequency of aberrant promoter …

BACKGROUND: We previously identified a number of genes which were methylated
significantly more frequently in the tumor compared to the non-cancerous lung tissues from …

DNA methylation markers provide a powerful tool to make diagnoses based on genetic
material obtained directly from tumors or from “remote” locations such as sputum, pleural …

Alterations in global DNA methylation have been observed in many cancers, but whether
such alterations represent an epigenetic difference in susceptibility for the disease is …

Aberrant methylation of promoter CpG islands is known to be a major inactivation
mechanism of tumor suppressor and tumor‐related genes. To determine the …

Genetic abnormalities of proto-oncogenes and tumor suppressor genes are well-known
changes that are frequently involved in lung cancer pathogenesis. However, another …

Lung cancer, caused by smoking in∼ 87% of cases, is the leading cause of cancer death in
the United States and Western Europe. Adenocarcinoma is now the most common type of …

Background Promoter hypermethylation coupled with loss of heterozygosity at the same
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …

Background Lung cancer is the leading cause of cancer death in men and women in the
United States and Western Europe. Over 160,000 Americans die of this disease every year …