JUSTIFICATIVA E OBJETIVO: O crescente uso de opioides para o tratamento da dor é uma
realidade em vários países. Com o aumento do uso aparecem questionamentos menos …

ß-Endorphin Modulates Immune Functions Page 1 Psychothcr. Psychosom. 42: 195-204 (1984)
© 1984 S. Karger AG. Basel 0033-3190/84/0424-0195S2.75/0 ß-Endorphin Modulates …

It is accepted that inflammatory mediators released from leukocytes contribute to the
generation of pain. However, it is less well known that immune cells also produce mediators …

Damage to the peripheral nervous system often leads to chronic neuropathic pain
characterized by spontaneous pain and an exaggerated response to painful and/or …

Despite the wealth of evidence in animals that immune activation has a key role in the
development and maintenance of chronic pain, evidence to support this in humans is scant …

Background Although inflammation induces pain, immune cells also produce mediators that
can effectively counteract it. To further elucidate the role of the immune response, we …

We have previously shown that β-endorphin (END) is contained and released from memory-
type T-cells within inflamed tissue and that it is capable to control pain (J Clin Invest 100 …

Although immunomodulating effects of opioids are well established, a final statement
regarding the clinical relevance cannot be made, since the existing clinical and …

Chronic pain represents one of the most serious worldwide medical problems, in terms of
both social and economic costs, often causing severe and intractable physical and …

This study utilized inhibitors of the enzymatic degradation of enkephalins to investigate the
possibility that this class of opioid peptides contributes to the stress-induced antinociception …