Abstract C3 glomerulopathy (C3G) is a recently identified disease entity caused by
dysregulation of the alternative complement pathway, and dense deposit disease (DDD) …

The progression rate of chronic kidney disease (CKD) to its terminal stage, end‐stage renal
disease (ESRD), and the development and severity of various complications, are at least …

Patient 1. A 19-year-old male was referred for evaluation of a glomerulopathy. Frequency of
micturition had been noted when he was 2.5 years old, and urinalysis at that time revealed …

Benign familial hematuria (BFH) is characterized by autosomal dominant inheritance,
thinning of the glomerular basement membrane (GBM) and normal renal function. It is …

We provide an overview of the principal phenotypes seen in chronic kidney disease with a
focus on the cystic diseases and ciliopathies, the glomerular diseases, disorders of renal …

BACKGROUND: Alport syndrome is a hereditary nephritis that may lead to end-stage renal
disease (ESRD) in young adult life and is often associated with sensorineural deafness …

The glomerular basement membrane (GBM) is a specialized form of basement membrane
that has a major role in the maintenance of the glomerular filtration barrier. Like all basement …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

Family members of individuals with chronic kidney disease are disproportionately affected
with unrecognized and asymptomatic nephropathy. Screening of these high-risk relatives for …

The recent discovery of genes involved in familial forms of nephrotic syndrome represents a
break-through in nephrology. To date, 15 genes have been characterized and several new …