The methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic
modification in mammalian genomes, and its abnormalities are intimately coupled to various …

Ten-eleven translocation 1–3 (Tet1–3) proteins have recently been discovered in
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …

DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, and X‐chromosome inactivation. Cancer cells display highly …

DNA methylation plays an important role in the epigenetic regulation of mammalian gene
expression. TET (ten-eleven translocation) proteins, newly discovered demethylases, have …

Discovery of the ten-eleven translocation 1 (TET) methylcytosine dioxygenase family of
enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the …

The mechanisms governing the methylome profile of tumor suppressors and oncogenes
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …

Background The ten-eleven translocation 1 (TET1) protein is a 5-methylcytosine
hydroxylase that belongs to the TET protein family of human α-ketoglutarate oxygenases …

Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the
demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation …

Maintenance of the balance of DNA methylation and demethylation is fundamental for
normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) …