Antidepressants are one of the first line treatments for neuropathic pain but their use is
limited by the incidence and severity of side effects of tricyclics and the weak effectiveness of …

Antidepressants remain one of the first line treatments prescribed to neuropathic pain
patients despite their limited efficacy and/or their numerous side effects. More and more …

Serotonin is critically involved in neuropathic pain. However, its role is far from being
understood owing to the number of cellular targets and receptor subtypes involved. In a rat …

There is an association between depression and chronic pain, and some antidepressants
exert antinociceptive effects in humans and laboratory animals. We examined the effects of …

Despite common pathophysiological mechanisms, inflammatory and neuropathic pain do
not respond equally to the analgesic effect of antidepressants, except for selective serotonin …

ABSTRACT Preclinical Research This work was performed to assess the effects of
intrathecal serotonin 2B (5‐HT2B) receptor antagonists in rats with neuropathic pain. With …

Antidepressants are one of the first-line treatments for neuropathic pain. Despite the
influence of serotonin (5-hydroxytryptamine, 5-HT) in pain modulation, selective serotonin …

Abstract Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT
receptors. The role of 5-HT 5A receptor in neuropathic pain has not previously studied. The …

This study assessed the role of systemic and spinal 5-HT7 receptors on rats submitted to
spinal nerve injury. In addition, the 5-HT7 receptors level in dorsal root ganglion and spinal …

Among receptors mediating serotonin actions in pain control, the 5-HT7R is of special
interest because it is expressed by primary afferent fibers and intrinsic GABAergic and …