From birth, children may need to take medication for acute or chronic diseases. Antibiotics,
anti-asthmatic drugs, antihistamines, analgesics, gastrointestinal drugs and attention …

The cytochrome P450 superfamily (CYP450) in humans is formed by 57 functional
monooxygenases critical for the metabolism of numerous endogenous and exogenous …

The aim of this review is to discuss our current understanding of the developmental changes
of the drug-metabolizing enzyme cytochrome P450 (CYP) 3A and its impact on drug therapy …

Cytochrome P450 enzymes play an important role in the pharmacokinetics, efficacy, and
toxicity of drugs. Age-dependent changes in P450 enzyme expression have been studied …

A paucity of data exists on the disposition and effect of drugs in young children. This
information gap can be reduced by elucidating developmental principles of absorption …

Advances in the basic and clinical sciences of drug actions and safety have been applied
almost exclusively to the largest demographic patient group–adults. Metabolism-dependent …

Pharmacokinetics varies widely between children. Many factors play an important role in this
variability, such as ontogeny, pharmacogenetics, gender, comorbidities, and drug-drug …

Drug–metabolizing cytochrome P450 enzymes, the major phase I enzymes, are active in
human liver already at very early stages of intrauterine development, although presumably …

Cytochrome P450 (CYP) superfamily represents the major drug metabolizing enzymes
responsible for metabolizing over 65% of therapeutic drugs, including those for pediatric …

Abstract Background and Objectives Current cytochrome P450 (CYP) 1A2 and 3A4
ontogeny profiles, which are derived mainly from in vitro studies and incorporated in …