Opioid receptor agonists are effective for treating pain; however, tolerance and dependence
can develop with repeated use. Combining opioids with cannabinoids can enhance their …

Rationale Opioids remain the drugs of choice for treating moderate to severe pain, although
adverse effects limit their use. Therapeutic utility might be improved by combining opioids …

Cannabinoid receptor agonists enhance the antinociceptive effects of μ-opioid receptor
agonists, which suggests that combinations of these drugs might enhance therapeutic …

Cannabinoid receptor agonists, such as Δ9-tetrahydrocannabinol (Δ9-THC), enhance the
antinociceptive effects of μ-opioid receptor agonists, which suggests that combining …

Opioids provide pain relief but are associated with several adverse effects. Researchers are
exploring cannabis-based medicine as an alternative. However, little is known about the …

We have previously reported that intracerebroventricular or intrathecal administration of
inactive doses of Δ9-tetrahydrocannabinol (THC) greatly enhance the antinociceptive …

The antinociceptive effect of peripheral Δ9-tetrahydrocannabinol was examined in mice
previously treated with an inactive dose of morphine. The ED50 of Δ9-tetrahydrocannabinol …

The effects of morphine and Δ 9-tetrahydrocannabinol (THC) on the tail-flick reflex, body
temperature, and catecholamine synthesis were examined in the mouse in order to compare …

Objective Cannabinoid receptor agonists such as delta-9-tetrahydrocannabinol (Δ 9-THC)
enhance the antinociceptive potency of mu opioid receptor agonists such as morphine …

The cannabinoid receptor agonist Δ 9-tetrahydrocannabinol (THC) enhances the
antinociceptive effects of µ-opioid receptor agonists, raising the possibility of using a …