The combinatorial pattern of DNA and histone modifications constitutes an epigenetic
'code'that shapes gene-expression patterns by enabling or restricting the transcriptional …

DNMT3 proteins are de novo DNA methyltransferases that are responsible for the
establishment of DNA methylation patterns in mammalian genomes. Here, we have …

ABSTRACT DNA methylation and histone modifications are two major epigenetic marks in
mammalian cells. Previous studies have revealed that these two mechanisms interact …

DNA methyltransferase 1 (DNMT1) is a multidomain protein believed to be involved only in
the passive transmission of genomic methylation patterns via maintenance methylation. The …

Using peptide arrays and binding to native histone proteins, we show that the ADD domain
of Dnmt3a specifically interacts with the H3 histone 1–19 tail. Binding is disrupted by di-and …

DNA methylation plays a central role in the epigenetic regulation of gene expression during
development and disease. Remarkably, the complex and changing patterns of genomic …

DNA methylation and histone modification are two major epigenetic pathways that interplay
to regulate transcriptional activity and other genome functions. Dnmt3L is a regulatory factor …

DNA methylation is a central epigenetic modification that is established by de novo DNA
methyltransferases. The mechanisms underlying the generation of genomic methylation …

Proper DNA methylation patterns are essential for mammalian development and
differentiation. DNA methyltransferases (DNMTs) primarily establish and maintain global …

DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is
thought to be the enzyme primarily responsible for maintenance of the global methylation …