Type I interferons (IFNs) are secreted by many cell types upon stimulation via pattern
recognition receptors and bind to IFN-α/β receptor (IFNAR), which is composed of IFNAR1 …

The antiviral activities of type I IFNs have long been established. However, comparatively
little is known of their role in defenses against nonviral pathogens. We examined here the …

Mice with a null deletion mutation in the gamma interferon (IFN-γ) receptor gene were used
to study the role of IFN-γ responsiveness during experimental pulmonary cryptococcosis …

Type III interferons (IFN-λs) are the most recently found members of the IFN cytokine family
and engage IFNLR1 and IL10R2 receptor subunits to activate innate responses against …

We examined the role of interleukin (IL)-4 in host resistance against infection with
Cryptococcus neoformans. First, we examined the effects of a neutralizing anti-IL-4 …

Interleukin-1 alpha (IL-1α) and interleukin-1 beta (IL-1β) are pro-inflammatory cytokines that
are induced after Cryptococcus neoformans infection and activate the interleukin-1 receptor …

Histoplasma capsulatum is the most common cause of fungal respiratory infections and can
lead to progressive disseminated infections, particularly in immunocompromised patients …

Type I interferons (IFN-I) are crucial in antiviral host defense. However, increasing evidence
suggests that IFN-I also play important roles during infections with nonviral pathogens. IFN-I …

Invasive fungal infections by Candida albicans (Ca) are a frequent cause of lethal sepsis in
intensive care unit patients. While a contribution of type I interferons (IFNs-I) in fungal sepsis …

Excessive or persistent inflammation may have detrimental effects on lung structure and
function. Currently, our understanding of conserved host mechanisms that control the …