[HTML][HTML] Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation
The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …
specific gene expression programs during multicellular development. In addition to …
Sequence determinants, function, and evolution of CpG islands
A Angeloni, O Bogdanovic - Biochemical Society Transactions, 2021 - portlandpress.com
In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with∼
80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with …
80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with …
[HTML][HTML] CpG islands recruit a histone H3 lysine 36 demethylase
In higher eukaryotes, up to 70% of genes have high levels of nonmethylated
cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units …
cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units …
Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved
DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …
CpG islands and the regulation of transcription
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …
[HTML][HTML] R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters
PA Ginno, PL Lott, HC Christensen, I Korf, F Chédin - Molecular cell, 2012 - cell.com
CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of
these elements remain protected from CpG methylation, a prevalent epigenetic modification …
these elements remain protected from CpG methylation, a prevalent epigenetic modification …
CpG islands influence chromatin structure via the CpG-binding protein Cfp1
JP Thomson, PJ Skene, J Selfridge, T Clouaire, J Guy… - Nature, 2010 - nature.com
CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base
composition and high density of CpG dinucleotides,. Most human gene promoters are …
composition and high density of CpG dinucleotides,. Most human gene promoters are …
[HTML][HTML] Understanding the relationship between DNA methylation and histone lysine methylation
DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …
become clear that the DNA and histone lysine methylation systems are highly interrelated …
[HTML][HTML] Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks
MA Hahn, X Wu, AX Li, T Hahn, GP Pfeifer - PloS one, 2011 - journals.plos.org
To elucidate the relationship between intragenic DNA methylation and chromatin marks, we
performed epigenetic profiling of chromosome 19 in human bronchial epithelial cells …
performed epigenetic profiling of chromosome 19 in human bronchial epithelial cells …
DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease
DM Jeziorska, RJS Murray… - Proceedings of the …, 2017 - National Acad Sciences
The human genome contains∼ 30,000 CpG islands (CGIs). While CGIs associated with
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …