The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …

DNA methylation is an important component of epigenetic modifications that influences the
transcriptional machinery and is aberrant in many human diseases. Several methods have …

With the rapid development of genome-wide high-throughput technologies, including
expression arrays, SNP arrays and next-generation sequencing platforms, enormous …

DNA methylation is an epigenetic mechanism that is related to mammalian cellular
differentiation, gene expression regulation, and disease. In several studies, DNA …

Motivation: Recently there has been increasing interest in the effects of cell mixture on the
measurement of DNA methylation, specifically the extent to which small perturbations in cell …

Background DNA methylation offers an excellent example for elucidating how epigenetic
information affects gene expression. β values and M values are commonly used to quantify …

Background The impact of cell-composition effects in analysis of DNA methylation data is
now widely appreciated. With the availability of a reference data set consisting of DNA …

Background Epigenome-wide association studies of human disease and other quantitative
traits are becoming increasingly common. A series of papers reporting age-related changes …

An outstanding challenge of epigenome-wide association studies (EWASs) performed in
complex tissues is the identification of the specific cell type (s) responsible for the observed …

Epigenetic marks such as DNA methylation have generated great interest in the study of
human disease. However, studies of DNA methylation have not established population …