Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of …
C Tayama, V Romanelli, A Martin-Trujillo… - Genome …, 2014 - genome.cshlp.org
Differential methylation between the two alleles of a gene has been observed in imprinted
regions, where the methylation of one allele occurs on a parent-of-origin basis, the inactive …
regions, where the methylation of one allele occurs on a parent-of-origin basis, the inactive …
Pervasive polymorphic imprinted methylation in the human placenta
The maternal and paternal copies of the genome are both required for mammalian
development, and this is primarily due to imprinted genes, those that are monoallelically …
development, and this is primarily due to imprinted genes, those that are monoallelically …
Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies
RKC Yuen, R Jiang, MS Penaherrera… - Epigenetics & …, 2011 - Springer
Background Genomic imprinting is an important epigenetic process involved in regulating
placental and foetal growth. Imprinted genes are typically associated with differentially …
placental and foetal growth. Imprinted genes are typically associated with differentially …
Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta
H Hamada, H Okae, H Toh, H Chiba, H Hiura… - The American Journal of …, 2016 - cell.com
DNA methylation is globally reprogrammed after fertilization, and as a result, the parental
genomes have similar DNA-methylation profiles after implantation except at the germline …
genomes have similar DNA-methylation profiles after implantation except at the germline …
Human oocyte-derived methylation differences persist in the placenta revealing widespread transient imprinting
Thousands of regions in gametes have opposing methylation profiles that are largely
resolved during the post-fertilization epigenetic reprogramming. However some specific …
resolved during the post-fertilization epigenetic reprogramming. However some specific …
Genomic landscape of human allele-specific DNA methylation
DNA methylation mediates imprinted gene expression by passing an epigenomic state
across generations and differentially marking specific regulatory regions on maternal and …
across generations and differentially marking specific regulatory regions on maternal and …
Imprinting mechanisms
A number of recent studies have provided new insights into mechanisms that regulate
genomic imprinting in the mammalian genome. Regions of allele-specific differential …
genomic imprinting in the mammalian genome. Regions of allele-specific differential …
Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome
Differential methylation of the two parental genomes in placental mammals is essential for
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …
Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes
C Proudhon, R Duffié, S Ajjan, M Cowley, J Iranzo… - Molecular cell, 2012 - cell.com
Identifying loci with parental differences in DNA methylation is key to unraveling parent-of-
origin phenotypes. By conducting a MeDIP-Seq screen in maternal-methylation free …
origin phenotypes. By conducting a MeDIP-Seq screen in maternal-methylation free …
Identification of novel imprinted genes in a genome-wide screen for maternal methylation
A characteristic of imprinted genes is that the maternal and paternal alleles show differences
in methylation. To perform a genome-wide screen for novel imprinted loci, we applied …
in methylation. To perform a genome-wide screen for novel imprinted loci, we applied …