Dynamics of DNA methylation in aging and Alzheimer's disease
HA Irier, P Jin - DNA and cell biology, 2012 - liebertpub.com
Gene expression is modulated by epigenetic factors that come in varying forms, such as
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …
Dynamic regulation of DNA methylation and brain functions
J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …
[HTML][HTML] Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
L Chouliaras, D Mastroeni, E Delvaux, A Grover… - Neurobiology of …, 2013 - Elsevier
Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders
G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …
corresponding gene expression. During the developmental stage, embryonic stem cells …
[HTML][HTML] DNA modifications and neurological disorders
Mounting evidence has recently underscored the importance of DNA methylation in normal
brain functions. DNA methylation machineries are responsible for dynamic regulation of …
brain functions. DNA methylation machineries are responsible for dynamic regulation of …
DNA methylation, a hand behind neurodegenerative diseases
H Lu, X Liu, Y Deng, H Qing - Frontiers in aging neuroscience, 2013 - frontiersin.org
Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …
Uncovering the role of the methylome in dementia and neurodegeneration
HU Klein, PL De Jager - Trends in molecular medicine, 2016 - cell.com
Our understanding of the epigenome has advanced dramatically over the past decade,
particularly in terms of DNA methylation, a modification found throughout the genome …
particularly in terms of DNA methylation, a modification found throughout the genome …
Epigenetics of aging
MI Sierra, AF Fernández, MF Fraga - Current Genomics, 2015 - ingentaconnect.com
The best-known phenomenon exemplifying epigenetic drift (the alteration of epigenetic
patterns during aging) is the gradual decrease of global DNA methylation. Aging cells …
patterns during aging) is the gradual decrease of global DNA methylation. Aging cells …
The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …