Gene expression is modulated by epigenetic factors that come in varying forms, such as
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …

Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …

Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …

Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …

Our understanding of the epigenome has advanced dramatically over the past decade,
particularly in terms of DNA methylation, a modification found throughout the genome …

Mounting evidence has recently underscored the importance of DNA methylation in normal
brain functions. DNA methylation machineries are responsible for dynamic regulation of …

The best-known phenomenon exemplifying epigenetic drift (the alteration of epigenetic
patterns during aging) is the gradual decrease of global DNA methylation. Aging cells …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …