There is increasing evidence that epigenetic alterations may play a role in Alzheimer's
disease (AD); yet, there is little information regarding epigenetic modifications in specific cell …

DNA methylation plays a critical role in brain aging and Alzheimer's disease (AD). While
prior studies have largely focused on testing mean DNA methylation, DNA methylation …

Cytosine DNA methylation is a stable epigenetic modification with established roles in
regulating transcription, imprinting, female X-chromosome inactivation, and silencing of …

Aging is a multi-factorial process of the progressive gradual decline of cellular functions with
the passage of time. It is clear that aging affects the mammalian epigenome, including …

Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …

Background Changes to the epigenome with aging, and DNA modifications in particular,
have been proposed as a central regulator of the aging process, a predictor of mortality, and …

Epigenomic settings control gene regulation in both developing and postmitotic tissue,
whereas abnormal regulation of epigenomic settings has been implicated in many …

Recent observations suggest that DNA methylation plays an important role in memory and
long-term potentiation (LTP) in the hippocampus and is involved in programming the …

Neurogenesis is not limited to the embryonic stage, but continually proceeds in the adult
brain throughout life. Epigenetic mechanisms, including DNA methylation, histone …

The central nervous system has a pattern of gene expression that is closely regulated with
respect to functional and anatomical regions. DNA methylation is a major regulator of …